| Office of the Chair Alex Hoehn-Saric | Contact Form | | |
| Office of Commissioner Mary T. Boyle | Contact Form | | |
| Office of Commissioner Richard Trumka Jr. | Contact Form | | |
| Office of Commissioner Peter Feldman | Contact Form | | |
| Office of Commissioner Douglas Dziak | Contact Form | | |
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| Office of Legislative Affairs | | | |
| Director - Matt Alpert | Contact Form | (301) 504 7853 | |
| Deputy Director - Andrew Ginsburg | Contact Form | (301) 504 7853 | (978) 967 2797 |
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| Office of the Inspector General | | | |
| Inspector General - Christopher Dentel | Contact Form | (301) 504 7905 | (301) 504 7004 |
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| Office of Equal Employment Opportunity, Diversity and Inclusion | | | |
| Director - Brittany Woolfolk | Contact Form | (301) 504 7596 | (301) 504 0107 |
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| Office of Communications | | | |
| Director - Pamela Rucker Springs | Contact Form | (301) 504 7882 | |
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| Office of the General Counsel | | | |
| General Counsel - Jessica Rich | Contact Form | (301) 504 7049 | |
| Office of the Secretary - Alberta Mills | Contact Form | (301) 504 7479 | (301) 504 0127 |
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| Office of the Executive Director | | | |
| Executive Director - Austin Schlick | Contact Form | (301) 504 7126 | |
| Deputy Executive Director: Safety Operations – DeWane Ray | Contact Form | (301) 504 7126 | |
| Deputy Executive Director: Operations Support – Annette Evans | Contact Form | (301) 504 7126 | |
| Deputy Executive Director: Outreach - Monica Summitt | Contact Form | (301) 504 7126 | |
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| Office of Compliance and Field Operations | | | |
| Assistant Executive Director – Robert Kaye | Contact Form | (301) 504 6960 | |
| Deputy Assistant Executive Director Jen Sultan | Contact Form | | |
| Director, Division of Field Investigations - Beverly Kohen | Contact Form | (516) 938 5215 | (866) 686 7937 |
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| Office of Hazard Identification and Reduction | | | |
| Assistant Executive Director – Duane Boniface | Contact Form | (301) 504 7671 | (301) 504 0038 |
| Deputy Assistant Executive Director – Joel Recht | Contact Form | (301) 987 2036 | (978) 367 9122 |
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| Directorate for Epidemiology | | | |
| Associate Executive Director - Steve Hanway | Contact Form | (301) 504 7256 | |
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| Directorate for Health Sciences | | | |
| Associate Executive Director - Mary Kelleher | Contact Form | (301) 987 2561 | |
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| Directorate for Engineering Sciences | | | |
| Associate Executive Director - Mark Kumagai | Contact Form | (301) 987 2234 | |
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| Directorate for Laboratory Sciences | | | |
| Associate Executive Director - Andrew Stadnik | Contact Form | (301) 987 2037 | (978) 367 1824 |
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| Directorate for Economic Analysis | | | |
| Associate Executive Director – Alex Moscoso | Contact Form | (301) 504 7782 | |
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| Office of Import Surveillance | | | |
| Director - James Joholske | Contact Form | (301) 504 7527 | |
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| Office of International Programs | | | |
| Director - Richard W. O'Brien | Contact Form | (301) 504 7054 | |
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| Office of Facilities Services | | | |
| Director - Mark Oemler | Contact Form | (301) 504 7058 | |
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| Office of Financial Management, Planning and Evaluation | | | |
| Chief Financial Officer - James Baker | Contact Form | (301) 574 7575 | |
| Deputy Chief Financial Officer - Casey Waithe | | (301) 504 7802 | (978) 367 9434 |
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| Office of Human Resource Management | | | |
| Director - Lyvette Wallace | Contact Form | (301) 504-7677 | (301) 504 0432 |
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| Office of Information Technology | | | |
| Assistant Executive Director and CIO - Bryan Burnett | Contact Form | (301) 504 7654 | |
